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Updated: Sep 19, 2024


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maxcryptosigna

September 16, 2024, 14:14

⏰#1: Liberal vs. restrictive transfusion strategy in traumatic brain injury

🕓10-second takeaway
Restrictive transfusion strategies for anemia are now accepted as an appropriate treatment for most critically ill patients, but the best transfusion strategy for minimizing neurological injury in traumatic brain injury (TBI) remains unclear. In this multicenter, international randomized trial, a liberal transfusion strategy did not significantly reduce the risk of unfavorable outcomes in ICU patients with a moderate or severe TBI at 6 months compared to a restrictive transfusion strategy. However, a liberal transfusion strategy was associated with better scores on some quality of life measures. A restrictive transfusion strategy for managing anemia in patients with a TBI may be appropriate, but further research is needed to assess the impact on nuanced measures of neurological recovery.

🔹Original study
Turgeon AF, Fergusson DA, Clayton L, et al. Liberal or restrictive transfusion strategy in patients with traumatic brain injury. N Engl J Med, 2024. doi: 10.1056/NEJMoa2404360